Endocrine Abstracts

Aim: The aim of this study was to evaluate metabolic abnormalities in young adults getting treatments of acute lymphoblastic leukemia (ALL) and brain tumors (BT) in their childhood.Methods: We examined 50 patients in two groups. The group-1: 18 ALL-survivors (nine women and nine men). All of them received cranial irradiation in dose up to 18 Gy and chemotherapy. In group-2: 32 BT-survivors (14 women and 18 men) were included. All patients received cranio...

Aim: The aim of this study was to examine the incidence of metabolic abnormalities in adults getting treatments of brain tumors (BT) and acute lymphoblastic leukemia (ALL) in their childhood or adolescence.Methods: patients were divided in two groups. In group 1: 31 BT survivors (13 women and 18 men) were included. All patients received craniospinal irradiation up to 36 Gy and boost to the tumor up to 55 Gy and chemotherapy. The group 2: 18 ALL survivors...

The patients following craniospinal irradiation (CSI) in young ages due to posterior fossa tumors had high risk of hypopituitarism. The glucagon stimulation test (GST) may be used as alternative the insulin tolerance test (ITT) in the diagnosis of GH deficiency (GHD) and central adrenal insufficiency (CAI) when insulin-induced hypoglycaemia is contraindicated e.g. history of convulsions, coronary heart disease, also it can be carry out as an outpatient. The aim of this study w...

The glucagon stimulation test (GST) may be used as a good alternative to the insulin tolerance test (ITT) in the diagnosis of secondary adrenal insufficiency (SAI). The aim of the study was to compare the GST and ITT for diagnostic SAI, to define cortisol cut-off points and factors affecting the appearance of false positive results in young adults followed CSI.Subjects and Methods: A retrospective study of 28 patients (median age 19 [17; 23]) at least 2 ...

Abstract: The secondary adrenal insufficiency (SAI) is life-threatening disease. 30–50% of patients have SAI following craniospinal irradiation (CSI). The “gold standard” of SAI diagnosis is the insulin tolerance test but it is demanding for patient and medical staff. The simple and reliable test would allow to use ITT rarely. The aim was to evaluate probability of using DHEA-S in SAI diagnosis. 41 patient after CSI non-pituitary brain tumors survivor and 23 hea...

The number of the non-pituitary brain tumors survives increases and will be growing up in the future. Although the prevalence of secondary adrenal insufficiency (SAI) vary depending on the methods of diagnostic, we have a few data about their ACTH and DHAE-S status. The aim of our study was to describe the hypotalamic-pituitary-adrenal axis (HPAA) changes after craniospinal irradiation (CRT) and diagnostic utility basal cortisol (BC), DHAE-S, glucagon stimulation test (GST) in...

Diabetes mellitus (DM) is accompanied with a variety of metabolic changes in different systems including bone. In several previous studies it was shown that DM type 1 is associated with a decreased mineral density, whereas the data regarding DM type 2 are still controversial.In the present study we examined the risk of different bone fractures in diabetic patients visiting local trauma clinic during one year (total area population 50.500). The incidence ...

Objective: To report a case of Cushing’s syndrome due to ectopic ACTH secretion and to evaluate role of somatostatin analogues for the localization and postoperative treatment of adrenocorticotropin-secreting bronchial carcinoid tumor.Methods: We describe the clinical presentation of our case and discuss its management.Results: A 57-year-old woman presented with symptoms and physical findings strongly suggestive of Cushing syn...